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Parameters That Increase Chance Of Aspartame Toxicity

Here Anna Robb details that whioch increases the risks of aspartame poisening:


It took very many years to have ingested the amount of aspartame that has taken me months to purge from my body. I estimate the amount within my body to be within 1-2 kg. As stomach acid and folate deficiency increases with age, as will rate of accumulation.

MTHFR Variant:

Having a severe MTHFR Variant and/or one which prevents synthetic folic acid ingestion(C667T)  puts you at risk.25


Synthetic folic acid for C667T carriers inhibits folate as it sits in the folate receptors, this then will lower pepsin as it makes you paradoxically more folate deficient 4. Chondroitin sulphate is shown to inhibit pepsin. 26


Those in poverty 27, even worse with severe MTHFR variants.
Poor diet causing folate deficiency.28
Reduced metabolic rate due to poor diet, e.g. anything that increases insulin, which is in a hyperactive state due to aspartame, this causes the blood sugar levels to drop, cortisol then is secreted to increase blood sugar levels.29 Cortisol lowers metabolic rate by;30,31

1. Cortisol decreases TSH (thyroid stimulating hormone), lowering thyroid hormone production.
2. Cortisol inhibits the conversion of T4 to active T3, and increases the conversion of T4 to reverse T3.
T4 is in active thyroid hormone, or storage thyroid hormone.T3 (Triiodothyronine) is the “bio-active” thyroid hormone that acts in the body. Reserve T3 is a type of T3 which has no ability to carry out tasks in the body. 72

Over the counter medicines:

Low stomach acid (hypochorlidia)is a result of folate deficiency and is known to cause acid reflux due to pressure. 32

Over the counter antacid remedies lower pepsin activation by either increasing stomach PH or by directly inhibiting pepsin activation:

Bismuth subsalicylate 33, Calcium carbonate 34, aluminium hydroxide 34, Sodium Alginate 35, Sodium bicarbonate/sodium hydrogen carbonate 36, Magnesium carbonate 37, Magnesium hydroxide 38, Magnesium Sulphate 39, ranitidine 40, esomeprazole 41.

Prescription medicines:

pepstatin 42, sufotidine 43, Amylopectin Sulphate 26, Dioctyl sodium sulphosuccinate 44, Riopan 45, Cimetidine 46, Propranolol possibly47.

Contraceptive Pill:

Known to lower folate levels which further lowers pepsin 48. Oestrogen based will vastly lower metabolic rate by causing low T3 uptake 49. Progesterone(Cerelle) stimulates dopamine 50, which will increase the cushing’s like nature of aspartame.


It lowers the metabolic rate by means of increasing insulin ,which lowers blood sugar which in turn increases cortisol, lowering your metabolic rate. Aspartame reduces pancreatic enzymes resulting in even less folate being absorbed from food. 51


Working outside in very hot temperatures for several hours breaks down aspartame. It starts to break down at temperatures over 30 degrees.52


Folate deficiency/Stomach acid is known to have dropped quite significantly by age 30 then more as you age. 19

Alcohol Consumption:

Chronic and heavy alcohol consumption is associated with diminished absorption of folate.53

: Smoking is also associated with low folate status. In one study, folate concentrations in blood were about 15% lower in smokers compared to non-smokers.53

List of References

Source: Anna Robb

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